Description
Product Characteristics: Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Inhibited by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is enhanced by high cytoplasmic calcium levels, due to activation of the protein phosphatase calcineurin. The volatile anestetic isoflurane enhances potassium currents. Tissue specificity: Detected in brain cortex, cerebellum, dorsal root ganglion, spinal cord and testis. Subcellular location: Membrane, Multi-pass membrane protein.,Outward Rectifier,Potassium channel subfamily K member 18, Two-pore-domain potassium channel TRESK, KCNKI
Target Information: mouse homolog induces a time-independent, noninactivating K+ current [RGD, Feb 2006]